Cortical Bone Mechanical Properties Are Altered in an Animal Model of Progressive Chronic Kidney Disease
نویسندگان
چکیده
منابع مشابه
Cortical Bone Mechanical Properties Are Altered in an Animal Model of Progressive Chronic Kidney Disease
Chronic kidney disease (CKD), which leads tocortical bone loss and increasedporosity,increases therisk of fracture. Animal models have confirmed that these changes compromise whole bone mechanical properties. Estimates from whole bone testing suggest that material properties are negatively affected, though tissue-level assessmentshavenot been conducted. Therefore, the goal of the present study ...
متن کاملRaloxifene improves skeletal properties in an animal model of cystic chronic kidney disease
Patients with chronic kidney disease (CKD) have an increased risk of fracture. Raloxifene is a mild antiresorptive agent that reduces fracture risk in the general population. Here we assessed the impact of raloxifene on the skeletal properties of animals with progressive CKD. Male Cy/+ rats that develop autosomal dominant cystic kidney disease were treated with either vehicle or raloxifene for ...
متن کاملThe Influence of Chronic Kidney Disease on the Structural and Mechanical Properties of Canine Bone
BACKGROUND Chronic kidney disease (CKD) is common in companion animals. Secondary hyperparathyroidism is an inevitable consequence of the disease and may have deleterious effect on the bone; however, the information regarding CKD-associated bone abnormalities in companion animals is scarce. HYPOTHESIS/OBJECTIVES Dogs with CKD have decreased bone quality compared to dogs without CKD. ANIMALS...
متن کاملEarly Detection of Progressive Chronic Kidney Disease
.............................................................................................................................................. ii ACKNOWLEDGEMENTS .......................................................................................................................... iii TABLE OF CONTENTS ............................................................................................
متن کاملMetabolic bone disease in chronic kidney disease.
Metabolic bone disease is a common complication of chronic kidney disease (CKD) and is part of a broad spectrum of disorders of mineral metabolism that occur in this clinical setting and result in both skeletal and extraskeletal consequences. Detailed research in that past 4 decades has uncovered many of the mechanisms that are involved in the initiation and maintenance of the disturbances of b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0099262